Hatters goalkeeper Mark Tyler will make his 250th appearance for Luton after being named in goal at Burton Albion this afternoon.
Town boss John Still made two changes to the side that beat Tranmere Rovers as Shaun Whalley came in for only second start of the campaign, while Scott Griffiths also returned at left back.
Leading scorer Mark Cullen dropped to the bench as did centre half Fraser Franks.
Rovers: Jon McLaughlin, Phil Edwards, Shane Cansdell-Sherriff, John Mousinho (C), George Taft, Robbie Weir, Stuart Beavon, Alex MacDonald, Damien McCrory, Adam McGurk, Matty Palmer.
Subs: Chris Weale, Lee Bell, Jacob Blyth, Bryn Morris, Liam Slade, Joe Doyle, Marcus Harness.
Hatters: Mark Tyler, Michael Harriman, Steve McNulty (C), Luke Wilkinson, Scott Griffiths, Shaun Whalley, Jonathan Smith, Luke Doyle, Jake Howells, Luke Guttridge, Paul Benson.
Subs: Elliot Justham, Fraser Franks, Andy Drury, Mark Cullen, Luke Rooney, Pelly Ruddock Mpanzu, Ricky Miller.