With the Africa Cup of Nations and the Asian Cup both starting this month, Premier League clubs will see a number of their players head to the Ivory Coast and Qatar for the tournaments.
The Luton News has taken a look at just who will be missing for the top flight sides in this gallery below.
17. Sheffield United
AFCON: Yasser Larouci (Algeria); Anis Slimane (Tunisia). Photo: George Wood
18. Tottenham Hotspur
AFCON: Yves Bissouma (Mali); Pape Matar Sarr (Senegal). ASIAN CUP: Son Heung-min (South Korea, pictured). Photo: Julian Finney
19. West Ham United
AFCON: Nayef Aguerd (Morocco); Mohammed Kudus (Ghana). Photo: Justin Setterfield
20. Wolverhampton Wanderers
AFCON: Rayan Ait-Nouri (Algeria); Boubacar Traore (Mali). ASIAN CUP: Hwang Hee-chan (South Korea); Justin Hubner (Indonesia). Photo: Jack Thomas - WWFC