The Hatters dominated the play and went into the break a goal up thanks to Cameron Jerome's effort, but a second-half comeback from the visitors saw them snatch victory with two second half goals.
The result saw Luton end the weekend still outside of the play-off places, but slip-ups from their fellow promotion chasing sides means they're still just missing out on the top six.
Speaking after the game, Hatters boss Nathan Jones said: "I feel low, I’ve got to be honest with you, the manner of it, just disappointed.
The decisions to give them the goals were poor, I felt we were decent all afternoon, we were excellent first half and this is a tough one to take.
“These never have got to to play well to beat us. I don’t know what it is, because we have chance after chance against them away from home, and we gift them the goals and then here exactly the same.
“Just stay on your feet, you don’t have to dive in, so I’m just disappointed with the goals, it’s killed me and I’m finding it hard to speak.
Next up, Luton take on Preston North End tomorrow evening, and will be out for revenge after losing 2-0 away to the Lilywhites in the corresponding fixture last October.
Take a look at the latest news and transfer stories from the second tier, as the reaction to last weekend's action continues:
1. Joseph targets Swans breakthrough
Swansea City youngster Kyle Joseph has targeted securing a starting spot for the side, after impressing during a loan spell at Cheltenham Town. He impressed for the U23 side earlier in the week, scoring four times in a win over QPR. (Club website)
2. Baggies starlet tipped to thrive
Ex-footballer Kevin Phillips has backed West Brom youngster Taylor Gardner-Hickman to become a star player for the Baggies. He’s described the defender as the “jewel in the crown” that manager Steve Bruce has been crying out for. (Football League World)
3. Hammer tipped to win Johnstone race
West Ham are said to still be leading the race to sign West Brom goalkeeper Sam Johnstone, despite interest from the likes of Rangers and Man Utd. The England international looks set to leave the Baggies upon the expiry of his contract this summer. (HITC)
4. Sharp to stay?
Sheffield United boss Paul Heckingbottom has revealed he’s optimistic that talisman striker Billy Sharp will remain at the club for another year. The Blades have an option to extend his contract, and the skipper has admitted he’s keen to stay. (The Star)